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This local delivery also ensures rapid symptom relief, which is particularly valuable for respiratory diseases such as asthma, chronic obstructive pulmonary disease and cystic fibrosis 99,111,112

Prior clinical studies questioned whether older RBCs are equally safe and effective as fresh RBCs, utilizing endpoints such as a multiple organ dysfunction score (MODS) [25], mortality [28] or other combinations of morbidity and mortality [29, 30]

J S Ji acknowledges support from Tsinghua University International Cooperation Special Project of Initiative Scientific Research Program