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Circulatory symptoms You might notice breathlessness even while sitting still, a rapid heartbeat, or unusually pale skin

It has been suggested that the heterogeneity of patients with COPD necessitates different treatment strategies for different subgroups of patients [31]

This diet-microbiota-metabolite-immune axis unifies diverse dietary strategies, as each intervention modulates microbial flux toward metabolites that activate conserved anti-tumor pathways (e.g., HDAC inhibition, AhR signaling, STING activation) while mitigating metabolite-driven immunosuppression

Collectively, these advances will shift probiotic therapy from a broad-spectrum supplement to a precision modulator, delivering efficient, stable, and personalized next-generation microecological treatments for the clinical management of UC