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Canakinumab, an interleukin-1 inhibitor, in patients with prior MI and elevated CRP, provided strong evidence for a significant reduction in the risk of recurrent MI, stroke, and cardiovascular death (Ridker et al., 2017)

This inhibitory effect of heme on macrophage phagocytosis and chemotaxis occurs through the activation of the GTP-binding Rho family protein Cdc42 by DOCK8, a guanine nucleotide exchange factor, disrupting actin cytoskeletal dynamics (102)

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Intensification of hyper-CVAD with L-asparaginase, vincristine, and dexamethasone(augmented hyper-CVAD) has activity in adult patients with relapsed/refactory acute lymphoblastic leukemia (ALL)