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You should not use methotrexate if youre pregnant or could become pregnant

211,212 When GSDMD induced pore formation in the mitochondrial membrane, one of the consequences is the escape of mtDNA to form DAMPs

Cancer 13 , 714726 (2013)

10.1093/cercor/bhy196 Summary Keywords epilepsy, astrocytes, glutamate transporters, metabotropic glutamate receptors, GLT-1, GLAST, mGluR3, mGluR5 Citation Peterson AR and Binder DK (2020) Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy