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Specially, 20S proteasome inhibitors bortezomib, carfilzomib, and ixazomib, which mainly target the CT-like catalytic subunit of the proteasome 5 subunit, are approved to treat patients with certain cancers, such as multiple myeloma

Additionally, endotoxin levels are verified using the LAL test (Limulus Amebocyte Lysate) to exclude contamination

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Individuals with defects of methylmalonyl CoA mutase or polymorphisms occurring in the genes that code for enzymes in the cobalamin adenosylation pathway, may also have low serum vitamin B12 levels (Kano et al., 1985)