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Nutrient depletion in the lung TME deprives effector T cells of glucose, glutamine, and arginine, while simultaneously enhancing Treg and MDSC suppressive activity, thereby weakening ICI efficacy

Navarro-Sanchez L, Agueda-Gomez B, Aparicio S, Perez-Tur J

Taken together, our analysis suggested that the R line could more actively mobilize these transmembrane signaling receptors or co-receptors to sense Xcc than the S line to activate the cabbages defense responses to Xcc infection (see Step 1 in the model, Figure 9 )