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doi: 10.3389/fpls.2013.00314 Received 30 May 2013 Accepted 26 July 2013 Published 16 August 2013 Volume 4 - 2013 Edited by Emmanuel Baudouin, Universit Pierre et Marie Curie - Paris 6, France Reviewed by Vasileios Fotopoulos, Cyprus University of Technology, Cyprus

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Methylation at R248 inhibits MDH1 post-translational mechanisms by disrupting MDH1 dimerization, which modulates mitochondrial respiration and glutamine-dependent production of NADPH in pancreatic cancer cells