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Description

Altered PKA signaling can disrupt cellular processes associated with dopamine release and neuroplasticity, leading to PD progression

(2019) 25:e12760

Increased glycolytic flux feeds its branching biosynthetic pathways, including the pentose phosphate pathway (PPP) for production of ribose and cytosolic NADPH, which sustain nucleotide synthesis and antioxidant activity, respectively, as well as one-carbon metabolism for mitochondrial NADPH production and nucleotide synthesis