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Previous studies have documented that an LPS stimulus decreases the circulating levels and hepatic expression of IGF-1, and leads to the inhibition of skeletal muscle protein synthesis (41,42)

however, the limited number of RCTs precludes definitive conclusions on the efficacy or safety of microbiome-based therapies, necessitating more RCTs for validation

As cachexia progresses, patients experience unconscious weight loss exceeding 5% within six months, accompanied by skeletal muscle atrophy

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