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Paseban M, Butler AE, Sahebkar A

Manega CM, Fiorelli S, Porro B, Turnu L, Cavalca V, Bonomi A, Cosentino N, Di Minno A, Marenzi G, Tremoli E, et al

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Age of onset Rarely before puberty Women: peak age 11 to 20 years Men: peak age 21 to 30 Major risk factors include: Obesity Tobacco Diabetes Mellitus Pathophysiology Three pathogenetic events (see image 2) Epidermal hyperkeratosis with occlusion and dilation Follicular epithelial wall rupture resulting in infiltration of inflammatory cells Formation of interconnecting sinus tracts Hurley Staging is a standardized staging system that describes the severity of HS and helps to guide treatment