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Description

Symptoms of B12 deficiency can include fatigue, weakness, pale skin, shortness of breath, dizziness, memory problems, mood changes, and tingling or numbness in the hands and feet

the resulting ester group may then be hydrolyzed and converted into acyl azide with DPPA, followed by Curtius rearrangement with an alcohol, such as tert-butanol, to provide the corresponding N-Boc protected substrate (not depicted)