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Therefore, the reduction in cortical BDNF delivery would result in diminished activity of the cortex and striatum synaptic activity and resulting in synaptic loss

doi: 10.3389/fmed.2018.00061

158 Available findings have allowed us to speculate that the biological activities of oxidized AAT may depend on the magnitude of AAT oxidation, in a manner similar to that discussed for HSA (Figure 3)