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Zhou ZD, Selvaratnam T, Lee JCT et al (2019) Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinsons disease

Another nuclear receptor, peroxisome proliferator-activated receptor (PPAR-), modulates gene expression related to inflammation and mediates antimycobacterial responses against M.tb infection by activating the expression of genes associated with autophagy, lysosomal function, and phagosomal maturation through lipid catabolism and upregulation of TFEB transcription[54]

Oxidative stress occurs when the excessive production of reactive oxygen species and reactive nitrogen species overwhelms the antioxidant systems ability to eliminate them 31

In those cases, the problem is fungal, not bacterial