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Alzheimers patients typically exhibit significantly decreased cerebral blood flow [50]

329 Paradoxically, a study showed that AML cell death after APR-246 treatment is inhibited by iron chelators, inhibitors of lipid peroxidation, and lipophilic antioxidants and is characterized by the accumulation of lipid peroxidation, thus meeting the definition of ferroptosis

doi: 10.3389/fphar.2025.1718803 Received 04 October 2025 Revised 07 November 2025 Accepted 10 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Giuseppe Remuzzi, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Italy Reviewed by Muhammad Saboor, University of Sharjah, United Arab Emirates Ferruh Artunc, University of Tbingen, Germany Updates Copyright 2025 Deng, Gong, Huang, Zhou and Ren

EJ bladder cancer cell line, MCF-7/MDR breast cancer cell line and 786-O renal cell carcinoma cell line were purchased from the Cell Culture Center of the Institute of Basic Medicine, Chinese Academy of Medical Sciences (Beijing, China)