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Compound 24 (Figure 21) demonstrated dose-dependent COX-2 inhibition and selectivity in successive enzymatic assays and reduced COX-2 expression in the peripheral blood cells of CIA rats

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doi:10.1016/j.bmcl.2004.12.080

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While throat discomfort may develop in some individuals taking GLP-1 medications, the underlying cause is often indirectstemming from nausea, reduced fluid intake, or gastrointestinal changes rather than semaglutide's direct action on throat tissue

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