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The findings indicate that microbial metabolite 4-ethylphenyl sulfate (4EPS) enters the brain and is associated with changes in region-specific activity and functional connectivity, including altered oligodendrocyte function, impaired oligodendrocyte maturation, and decreased oligodendrocyte-neuron interactions (Needham et al., 2022)

Preclinical studies have shown that NR supplementation in aged murine models significantly enhances mitochondrial function, leading to attenuation of cardiac hypertrophy and cognitive impairment

Patients with gastrointestinal diseases, like gastric ulcers, leaky gut, irritable bowel syndrome, and Crohns disease

This diet causes a rapid shift in bacterial flora within one to two weeks