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Scientific Background on TB-500 (Thymosin Beta-4 Fragment) TB-500 is the synthetic heptapeptide fragment (Ac-LKKTETQ-NH) of the naturally occurring 43-amino-acid protein Thymosin Beta-4 (T4)

doi: 10.1002/glia.20468 309 SikoraE.Bielak-ZmijewskaA.DudkowskaM.KrzystyniakA.MosieniakG.WesierskaM.et al

By fitting the plasma concentrations to a non-compartmental PK model 34 , we found that the IgG1-REW variants were present at higher concentrations in plasma over time (AUC) compared to WT, had slower clearance, longer mean residence time and lower volume of distribution at steady state (Table S4)

Dynamic simulations on the arachidonic acid metabolic network