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Healthcare providers advise against drinking alcohol while taking trazodone due to potential serious side effects and long-term health risks

The 3 helix is reduced to one turn in ChiA (L76-I80), and the insertion V150-L155 seen in ChiB is absent

This is a different approach and the early outcomes being studied are strong enough to make experts curious about whether the triple mechanism can translate into meaningful real-world benefits once larger trials confirm safety and long-term results