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9 A considerable amount of evidence suggests that glutathione depletion is an important risk factor for glaucoma

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(2019) demonstrated that AS-IV activates the Keap1/Nrf2 antioxidant pathway by downregulating Keap1 expression in the cytoplasm, promoting dissociation of Keap1 from Nrf2, facilitating Nrf2 release and translocation to the nucleus, where it binds Maf to initiate the transcription of the antioxidant gene HO-1

A literature review found that 200 mg/d of a standardized extract helps normalize the release of stress hormones while boosting energy metabolism (Anghelescu 2018)