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Challenges and Considerations While genetic testing offers numerous benefits, it is not without challenges

For instance, Mardikian et al [69] reported the occurrence of some mild side-effects between 1200, 2400 and 3600 mg/day oral doses of NAC, lying in parallel with the findings of Berk et al [70,71] who evaluated a daily dose of 2 g of NAC (1000 mg twice daily) and also perceived some mild adverse effects

It is currently in phase IIb trial aiming at recruiting 185 patients (NCT02665364)

For example, monoclonal antibodies to be used may be made by the hybridoma method first described by Koehler et al., Nature, 256: 495 (1975), or may be made by recombinant DNA methods (see, e.g., U.S