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In contrast, a variant called GMA5AC_V2, derived from carboxy-terminal -core motif of MtDef5A (GMA5AC), exhibited two-fold higher activity (MIC ~ 1.5 M) than GMA5AC (MIC ~ 3 M) against Bc

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PL7737 has comparable potency to small molecule agonists (MK-0493, bivamelagon) that were inefficacious in general obese populations and RM-718 is less potent on MC3R and MC4R than setmelanotide, raising concerns for potential lack of efficacy in future general obesity trials

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