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Similar content being viewed by others Introduction Ulcerative colitis (UC) is a severe chronic inflammatory illness of the gastrointestinal tract

Kynurenine is predominantly metabolized to the N -methyl-d-aspartate (NMDA) receptor agonist quinolinic acid (QUIN) in the inflammatory state, contributing to the accumulation of glutamate in the extracellular space, leading to changes in network connectivity associated with depression, fatigue and cognitive impairment

Ghosh, P., Han, G., De, M., Kim, C

Additionally, while 3T3-L1 adipocytes have been a workhorse cell line for studying GLUT4 biology, they are immortalised mouse cells, and the field would benefit from more translational adipocyte models, such as human-derived lines or tissues