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found that patients with T2DM, hyperlipidemia, coronary artery disease, polycystic ovary disease (PCOD), or obesity, and on metformin therapy were significantly associated with increased risk of vitamin B 12 deficiency and lower serum vitamin B 12 concentrations [9]

Acyl-CoA synthetase long-chain family member 4 (ACSL4), which is a key enzyme that regulates lipid composition, has been shown to contribute to the execution of ferroptosis

Additional research is exploring its role in angiogenic signaling, cellular turnover, and oxidative stress response pathways

A power analysis was not performed to determine the sample size