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J Clin Transl Hepatol 12(11):939948 Dutt S, Hamza I, Bartnikas TB

A statistically significant increase in Gln was observed after 48-h exposure to 100 mol/L CdCl and 100 or 200 mol/L cisPt

Voltage-dependent anion channel (VDAC) opening mediates metabolite influx into mitochondria, increasing OXPHOS and ROS production, causing mitochondrial dysfunction (Wang et al., 2020)

The change in abundance of the barcoded clones can be traced by subsampling the cell population over time and quantifying the DNA barcodes by PCR and deep sequencing