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Conclusions Murine gut microbiota mediated the anti-ferroptotic effect of metformin on IIRI, and the resulting increase in microbial GSH synthesis could serve as a critical pathway for anti-IIRI

doi: 10.1111/j.1365-2249.2008.03860.x 177 OschilewskiUKieselUKolbH

Ferroptosis inhibitors may offer precise regulation of ferroptosis in IBD through related signaling pathways in future

GPx3 mRNA is also detected in other tissues, such as liver, heart, breast, lung 4 , skeletal muscle, pancreas, brain 5 , mature absorptive epithelial cells 6 and thyroid 7 , from where Gpx3 is secreted into the surrounding extracellular environment