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doi: 10.3389/fimmu.2021.702764

150 Chronic fructose intake leads to gut flora dysbiosis, tight junction protein downregulation, secretory cell depletion, and elevated pro-inflammatory cytokines, thereby disrupting the gut barrier and triggering endotoxemia-mediated liver inflammation and fibrosis

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2.3.1 Chemical chaperones Chemical chaperones that alleviate ERS and oxidative stress have demonstrated consistent renoprotective effects across diverse AKI models