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In reviews of the literature published between 1999 and 2007, Daly-Youcef [4] and Andrs E [19] concluded that orally administered vitamin B12 provided effective treatment for adult and elderly patients with deficiencies, although they highlighted that further studies were needed to determine its effectiveness in patients with severe neurological symptoms

Among these agents, busulfan stands out as a notable representative frequently employed in the treatment regimen for patients before allogeneic hematopoietic stem cell transplantation, particularly those diagnosed with chronic myeloid leukemia [64]

doi: 10.1371/journal.pbio.2003992

In patients with moderate or severe liver injury, prednisolone should be administered with discontinuation of the causative drug