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Frontal lobe proton magnetic-resonance spectroscopy in Graves disease: a Pilot Study

INTRODUCTION Danoprevir (DNV) is a potent, macrocylic, second-generation HCV protease inhibitor that has similar in vitro activity against HCV genotypes 1, 4 and 6.[1,2] In the phase II ATLAS trial, the highest DNV dose arm (900 mg q12h) was prematurely discontinued due to reversible Grade 4 alanine aminotransferase (ALT) elevations in three patients.[3] Considering the role of reactive metabolites in drug-induced liver injury[4] the potential for DNV to form reactive metabolites was evaluated and the effect of low-dose ritonavir on the metabolic profile of DNV was investigated