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Contributing factors include: A diet high in sugar and processed fats[1] Exposure to environmental toxins like air pollution, pesticides and heavy metals[2] Cigarette smoke[3] and alcohol use[4] Infections and chronic inflammation[5] Intense or prolonged physical exertion[6] Psychological stress[7] Biochemically, oxidative stress is marked by an imbalance between oxidants and antioxidants, disrupting cellular signaling, promoting inflammation and weakening mitochondrial function.[8] Over time, this imbalance can lead to cumulative molecular damage, a foundational factor in aging and disease progression

Raised calcium promotes -synuclein aggregate formation

10.1186/s40101-022-00294-0

Ann Urol (Paris) 37:4750 Liu Y, Xu H, Zhong W, Shen Q, Zhuang T, Huang K (2015) Organic selenium alleviated the formation of ethylene glycol-induced calcium oxalate renal calculi by improving osteopontin expression and antioxidant capability in dogs