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SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal adenocarcinoma

In the brain of AD patients, A binds to the receptor on the cell membrane, activates the downstream RIPK1, and then phosphorylates RIPK3, leading to the phosphorylation and oligomerization of MLKL

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1 Introduction Autoimmune disorders represent a prominent class of pathologies defined by a breakdown in self-tolerance, where a dysregulated immune system attacks host tissues, thereby initiating localized or systemic inflammatory damages ( 2 Mechanism of ferroptosis Ferroptosis, a term coined by Dixon et al