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It was demonstrated how mutations in CYP2C19 influence the daily treatment of patients, leading to adverse drug reactions or therapeutic failure in many common diseases (Sienkiewicz-Oleszkiewicz and Wiela-Hojeska, 2018)

The usual care for ALS patients consists of treatments that slow the progression of the disease: to date, riluzole is the only treatment that has been shown to prolong survival in ALS (Miller and Appel, 2017)

Altered K ir and gap junction channels in temporal lobe epilepsy

6 At our institution, the standard-of-care protocol caps doses at 1 vial of glucarpidase (1000 units) because there is a lack of evidence to prove that higher doses of glucarpidase result in greater clinical benefit