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Cardiomyocytes are remarkably sensitive to changes in energy metabolism, and epigenetic modifications play an instrumental role in the initiation and progression of MI

As ebselen is already an FDA-approved drug, its repurposing as a radioprotective drug may be easier compared to any other new synthetic drug substance

Conversely, Lorenzini et al

Furthermore, heritability estimates range from 30 to 40% (Girgenti et al., 2021) with genome-wide studies implicating immune-linked loci such as ANKRD55 among others (Stein et al., 2016