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Methods Animals Thirty female SpragueDawley rats weighing 200 10 g were purchased from the Chinese Academy of Medical Sciences (Shanghai, China)

However, only Zileuton was approved for clinical therapy, which is believed to ligate the active iron through its N-hydroxy urea moiety [267]

Some other downstream genes regulated by Nrf2 may be related to cell-to-cell interactions, and the close cooperation and interactions between astrocytes, oligodendrocytes, microglia, and neurons are the basis for maintaining the function of the central nervous system and the normal life activities of living organisms