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In: PrakashBde So JosJFB, editors

OAPs) are more likely to have greater severity and/or duration of illness, a higher propensity for nonadherence, and increased risk of relapse [10, 14]

The positive circuit of NF-B activation and ROS production can accumulate more ROS in irradiated OSCC cells and this positive feedback regulation overcomes the pro-survival effect of NF-B/IL-6 signaling (90)