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The generated glutamate can directly participate in the synthesis of glutathione, or generate cysteine which is another substrate of glutathione synthesis through the coupled action of glutamate efflux mediated by SLC7A11 and cysteine uptake (Timmerman et al., 2013)

A.SoletiA.MollaceV.MuscoliC.SculcoF.et al (2010)

Radiation is more common in the treatment of liposarcomas that have already been surgically removed once before

Moreover, metformin rather stimulates the NADH:FeCN oxidoreduction reaction and does not alter the thermal stability of the flavin site, except at extremely high non-relevant concentration (200 mM), indicating that NADH oxidation occurring at the flavin site is probably not involved in the inhibition of complex 1 by the drug