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Unlike in HK-2 cells without GSH depletion, bismuth enhanced ubiquitin-mediated proteolysis, suggesting that without GSH, proteins are vulnerable upon bismuth treatment (Figure 2B, Supplementary Figure S2C)

The observed sustained release is likely attributable to the unique porous structure of the cryogel and the homogeneous distribution of EO droplets within the polymer network, which effectively modulates diffusion

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