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Other measures to target hypoxia include targeting hypoxia-induced signaling pathway proteins (such as HIF-PHD-pVHL pathway proteins and mTOR pathway proteins, etc.) and increasing oxygen supply through vascular normalization (such as the use of antiangiogenic drugs, etc.) (198200) ( Figure 3 )

Successful cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1