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Domen HM, Fierro-Carrin G

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (Nf)-kappab

However, this doesn't mean copper accumulation is impossible, particularly with long-term use or in individuals with impaired copper metabolism

The specific aspect of manuscript covered in patent application includes the use of genetic and pharmacological suppression of PrP for reduction of copper toxicity