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Dietary interventions in Cancer treatment and response: a comprehensive review

Mechanistic studies reveal that SFN significantly downregulates programmed death-ligand 1 (PD-L1) expression on tumor cells through multiple mechanisms, including direct covalent modification of cysteine residues on STAT1, which inhibits its transcriptional activity and blocks IFN--induced PD-L1 expression (75)

The disorder is thought to result from ciliary defects in cholangiocytes

Brain metabolism along with sleep impairment play a crucial role in deteriorating cellular and system homeostasis that contributes to cognitive decline as well as aging trajectories (Gonzales et al., 2022