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Exposure to light can cause the vitamin to degrade

Fontaine, K

Ideal candidates for B12 injections include patients with serum B12 levels below 200 pg/mL, elevated MMA or homocysteine, and clinical symptoms

The presence of the quaternary carbon at C 75.0 ppm is consistent with a ring B rearrangement, resulting in a spiro linkage between rings B and C of the corynanthe core (Figure S4)