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The duration of immobility was measured by an observer blind to the treatment conditions (Porsolt et al., 1978) after treatment with vehicle, only cannabis (5, 10 or 15 mg/kg, s.c.), fluoxetine, sertraline, imipramine or after cannabis (5 mg/kg) co-administered with the antidepressant drugs

Oral supplements, on the other hand, are partially broken down during digestion and work more gradually

And there's been quite a lot of research and interest just in mitochondrial health in general for aging, whether it's brain aging, whether it's immune aging, whether it's skin aging, just pretty much any system of the body that you can think of, mitochondrial decline is likely to be contributing to the decline in that system