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Therefore, nanotechnology is a very effective tool to increase the limits of native curcumin to improve its therapeutic potential due to the presence of other key features such as high cellular uptake, biodistribution, dissociation rates, stability in serum, and sustained drug release at the target site

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However, the clinical translation of such combination strategies still faces multiple challenges, including drug toxicity, cumulative side effects, dosage selection, and timing of administration

The downregulation of thyroid hormones, reduction in non-exercise activity thermogenesis (NEAT), and increased ghrelin signaling