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EWG green ingredients proved and passed the Skin Irritation Test, suitable for sensitive skin

626 In phase 2a, randomized, dose-finding, proof-of-concept study, NRD.E1 induced a clinically relevant pain reduction and was well tolerated

This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries)

In diabetes, diminished abundance of Akkermansia , Bacteroides , Bifidobacterium , Faecalibacterium , and Roseburia reduces -glucuronidase and 7-dehydroxylase activities, thereby blocking the conversion of primary BAs to secondary BAs and consequently decreasing the synthesis of DCA and LCA (Li et al., 2021b)