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Most of the alkamides tested revealed moderate intestinal absorption characteristics, as evidenced by the ADMET plot in Figure 8, where they were in the 99% absorption ellipse, with only compounds 5254 located outside the 99% absorption range

The liver is generally considered to be responsible for more than 90% of alcohol oxidation

Nat Chem Biol (2017) 13(1):918

Sajisevi M, Caulley L, Eskandr A, Du YJ, Auh E, Karabachev A, Callas P, Conradie W, Martin L, Pasternak J, Golbon B, Rolighed L, Abdelhamid Ahmed AH, Badhey A, Cheung AY, Corsten M, Forner D, Liu JC, Mavedatnia D, Meltzer C, Noel JE, Patel V, Sharma A, Tang AL, Tsao G, Venkatramani M, Williams M, Wrenn SM, Zafereo ME , Stack BC, Randolph GW, Davies L