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Therefore, while these preclinical findings are valuable for understanding LDHA as a target, their therapeutic readiness should not be overstated, and further research is crucial to assess their true clinical potential

Subjective and objective sleepiness increased significantly after restriction and returned to baseline after recovery

Metformin, a diabetes drug, alters the gut microbiome and increases SCFAs and bile acids that activate GLP-1, which has led to exploration of metformin in AD and PD trials for its possible MGBA benefits [278, 279]