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For instance, induction of iNOS in microglia leads to a decrease in cellular GSH level, whereas, under comparable conditions, the GSH status of astrocytes remains largely unaffected (Bolanos et al., 1994

Future mechanistic investigations are required to determine whether BTK inhibitors have any other advantages that are pertinent to MS patients such as reducing oxidative stress, removing iron and promoting remyelination [58]

Glucose oxidation during glycolysis produces ROS that are generally held in check by the cell's antioxidant defenses, including superoxide dismutase (SOD), thioredoxin, glutathione peroxidase (GP), and catalase [115]

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