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Cells, Nanomedicine, Biotechnol

doi: 10.1016/j.jid.2018.05.016 57 MullerADickmannsAReschCSchakelKHailfingerSDobbelsteinMet al

Release Through the Skin and Breath: Because the liver cannot keep up with the excess TMA, the strong-smelling compound circulates in the bloodstream and is expelled from the body through sweat, breath, and urine [10] [14]

354 Ammonium is mainly produced in the gut by amino acid deamination with subsequent conversion to ammonium by urease containing bacteria and is detoxified in the liver by the urea cycle enzymes and by glutamine synthetase, highly expressed in hepatocytes