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Description

Taken together, these in vivo data from multiple CRC models support our conclusion that inhibition of mitochondrial metabolism by metformin treatment can enhance the response of 5FU treatment by increasing tumour cell death and impeding tumour growth

qrt-PCR validated the increased expression of 26 genes involved in these pathways

Targeted overexpression of IGF1 in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury

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