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Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide

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In the detoxification process of a variety of exogenous substances (including drugs) that interact with tripeptides, the exogenous toxic substances are first oxidized by the hepatic cytochrome P-450 metabolic enzyme system, and then GST catalyzes the GSH sulfhydryl group to covalently interact with the electrophilic compound

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