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ruthenicum showed no significant difference in 28 days (Figure 1A), whereas the significant increases were observed in the exhaustive swimming duration in all experimental groups of mice (Figure 1B)

The authors acknowledge research support from the US Department of AgricultureAgricultural Research Service, the NIH (NIH-NIDDK R01-DK-078328 and R01-DK-078328-02S1) and the American Diabetes Association (1-12-BS-02)

The AR promoter had reduced accessibility as early as 5 days of SPA, which persisted at 26 days (Figure 5G), consistent with prior reports indicating that ligand-bound AR exhibits negative autoregulation at the level of AR gene transcription (31)

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